Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons
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چکیده
منابع مشابه
PGC-1α Turbocharging mitochondria
dinated with the neuronal differentiation program through the InR/TOR pathways? Cell growth is potently affected by the levels of InR or TOR activation in the ommatidial clusters, but growth per se cannot account for changes in the timing of differentiation, since induction of other growth regulators like dMyc or CyclinD/Cdk4 has no effect on the tempo of ommatidial differentiation. The InR and...
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Aging is the most significant risk factor for a range of degenerative disease such as cardiovascular, neurodegenerative and metabolic disorders. While the cause of aging and its associated diseases is multifactorial, mitochondrial dysfunction has been implicated in the aging process and the onset and progression of age-associated disorders. Recent studies indicate that maintenance of mitochondr...
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Mutations in the gene encoding Parkin are a major cause of recessive Parkinson's disease. Recent work has shown that Parkin translocates from the cytosol to depolarized mitochondria and induces their autophagic removal (mitophagy). However, the molecular mechanisms underlying Parkin-mediated mitophagy are poorly understood. Here, we investigated whether Parkin interacts with autophagy-regulatin...
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Objective(s): Exercise ameliorates the quality of life and reduces the risk of neurological derangements such as Alzheimer’s (AD) and Parkinson’s disease (PD). Irisin is a product of the physical activity and is a circulating hormone that regulates the energy metabolism in the body. In the nervous system, Irisin influences neurogenesis and neural differentiation in mic...
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Recent genetic and functional studies have revealed striking similarities in the protein networks and molecular mechanisms altered in cancer and Parkinson's disease, as illustrated here for the converging signaling pathways of parkin and Ret [1]. These similarities may guide our thinking about potential therapies for both diseases. The proto-oncogene RET encodes a receptor tyrosine kinase that ...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2017
ISSN: 0964-6906,1460-2083
DOI: 10.1093/hmg/ddw418